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In light of these findings, the elevated prefrontal GSH levels observed in participants with current but not remitted depression may reflect a compensatory upregulation in GSH levels, possibly in response to an increase in perceived stress, although no association between GSH and cortisol levels was observed

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[8] Since UVA is a major component of sunlight , the implication is that we evolved to rely on ergothioneine as part of our first-line defense against arguably the most common source of oxidative stress in the ancestral environment: sunlight

Most anti-aging interventions do one or the other