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In addition to the cardiovascular protection afforded by glucose metabolism regulation, a large body of evidence from animal and cellular studies has corroborated the beneficial effects of GLP-1 RAs on conditions such as heart failure (HF), hypertension, and ischemic cardiomyopathy

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The mechanism involves increased NAD+ levels in white adipose tissue, which activates sirtuins and AMPK signaling to shift cellular metabolism toward fatty acid oxidation

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