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When the production of free radicals exceeds the availability of antioxidants, oxidative stress occurs

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Administration with telmisartan for five weeks notably prevents the depression-like behaviors in OFT and SPT, and enhances expression of 5-HT transporter in the hippocampus of mice through activation of peroxisome proliferator-activated receptor , indicating RAS blockers improve stress-induced depressive symptoms in animals under chronic stress (164)

Magnesium and calcium, particularly in their citrate forms