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On the other hand, elevated levels of palmitoyl-L-carnitine are produced in aged mice, and they may cause mitochondrial disruption and contribute to the pathology of neurological diseases

If you are experiencing insomnia on semaglutide or constipation on semaglutide , switching to tirzepatide may or may not improve those specific symptoms, but the thirst issue will likely persist because the underlying GLP-1 mechanism is the same