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Statistical analyses were performed in R (R Core Team 2019, R Foundation for Statistical Computing, Vienna, Austria) using the R packages meta and netmeta [22], and in NMAstudio (version 2.0) web application [23, 24]

However, the results should not be interpreted as evidence that these medications prevent dementia, progressive cognitive decline, or psychiatric disease, because the study relied on diagnosis codes and remains vulnerable to residual confounding and misclassification

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A natural decline in overall caloric interest or minor dry mouth, which can be effortlessly managed with consistent daily hydration

Also, severe gastroparesis (delayed stomach emptying) can occur