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Thus, our study provides additional substantiation for the appropriateness of this model in simulating the environment wherein the replanted grafts reside post-transplantation, and investigating the mechanisms governing cell death

Glutamate accumulation to micromolar levels [375] results in GluN2B-mediated NMDA receptor overactivation, Ca 2+ overload, and subsequent tau hyperphosphorylation and dendritic spine collapse [376], linking excitotoxicity to amyloidogenesis [28]

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doi: 10.1038/nature10738 50 Quints-CardamaAKantarjianHMCortesJE