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Further, self-renewing RG have a higher rate of glycolysis with elevated lactate production and lower OXPHOS, evidenced by high hypoxia-inducible factor 1-alpha (HIF-1

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Other studies have shown that LXR activation can stimulate the transcription of the CD4+ T glycosphingolipid biosynthetic enzyme UGCG and enhance the lipid raft profile of the T plasma membrane, but additional related signaling pathways are also worth exploring (118)

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