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Both semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) work by regulating appetite and blood sugar, but they have distinct mechanisms and outcomes

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Despite their therapeutic efficacy, they are associated with metabolic side effects, most significantly steroid-induced hyperglycaemia (SIH) and steroid-induced diabetes (SID)

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Sample analysis was performed on an Agilent 1290 UPLC system equipped with a Waters BEH amide (2.1 mm 100 mm, 1.7 m) column using a gradient of 15 mM NHAc/0.3% NHOH in HO (A) and 90% ACN (B) at 0.3 mL/min