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The absence of dose-response studies means practitioners cannot scientifically tailor dosages to individual cosmetic objectives

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In the kindling model, chronic administration of subconvulsive doses of PTZ initiates the recurrence of seizures in a similar manner to the human epilepsy more than the acute models, where the seizure severity increases in a stepwise manner with each PTZ injection inducing severe generalized tonic-clonic seizures (Shimada and Yamagata 2018)

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Step 1: Obtain surgical clearance Never resume your medication without a direct yes from your surgeon