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Stress, micronutrient depletion, caloric restriction, over exercise, inflammation, pregnancy, breastfeeding, um, not sleeping well

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(3) It's also now starting to be observed and confirmed in these human trials, something that Lotte had noticed all the way back in the animal trial phase, that rats who were injected with very large amounts of liraglutide would stop eating

Together, these findings expand the clinical utility of GLP-1RAs to include kidney protection and symptom improvement in HFpEF, beyond their role in reducing major adverse cardiovascular events (Table 3)

Even though there is limited direct evidence to support this claim, its indirect effects are reasonable