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238,270 On the other hand, Cd II and Pb II responsive regulators Lm CadC 271 and Sa CadC 272,273 rely largely upon the 3 CxC motif and two N-terminal Cys as the primary allosteric site, denoted 3N, for negative regulation of DNA binding (Figure 6A, top ) since the 5 DxHx 10 Hx 2 (H/E) motif is either not present 274 or allosterically uncoupled (silent)