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Frizzled-8 (FZD8) as a Wnt receptor is known to be necessary for the interaction between the Wnt/-catenin axis and c-Met since it is upregulated through the ERK/c-Fos cascade by c-Met in cancer stem-like cells [106]
In reproductive settings, it could assist in healing uterine lining damage, support angiogenesis throughout the ovaries and endometrium, and regulate local inflammatory signals that can impede implantation
More severe side effects are rare but can include an allergic reaction or the development of blood clots
Blood vessel formation begins
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