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Oral administration demonstrates activity in gastrointestinal conditions despite lower systemic bioavailability, as direct mucosal exposure may contribute to therapeutic effects

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The underlying theory suggests that probiotics help alleviate symptoms by promoting the restoration of a healthier gut microbiota or through the beneficial metabolites they produce ( Lactobacillus and Bifidobacterium species that are everyday popular probiotic bacteria have mucosal trophic effects including stimulation of epithelial barrier function, inhibition of pathogen adhesion, regulation of existing microbiota and modulation immune system components ( Lactobacillus GG releases soluble molecules that in turn activate the p38 MAPK pathway that synthesizes heat-shock proteins to shield the intestinal epithelial cells from damage ( Bifidobacterium bifidum as well as L