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The accumulation of SAH can act as a negative feedback inhibitor of methyltransferase enzymes, emphasizing the importance of SAHH in maintaining methylation efficiency
Sulfur-rich foods support glutathione,an intracellular antioxidant that helps cells detoxify
Robaczewska J., Kedziora J., Kornatowska K
Ovarian cancer is the sixth most common malignancy among women in developed countries and the fifth leading cause of cancer-related death, representing a complex disease associated with poor survival rates.24 The combination chemotherapy of Paclitaxel (PTX) and Carboplatin (CARB) is considered the first-line treatment regimen for ovarian cancer.25 Both agents play distinct roles in inhibiting the growth of ovarian cancer through different mechanisms,26 and they are known to exert a synergistic anti-tumor effect by activating separate apoptotic signaling pathways, thereby potentially reducing drug resistance.25 The gonadotoxic effects of platinum-based chemotherapeutic agents have been demonstrated in numerous studies, both histopathologically and in terms of follicular development.27-29 In the present study, CARB administration led to significant histopathological damage in ovarian tissue, including follicular degeneration, prominent stromal edema, congestion, hemorrhage, inflammation, and fibrosis, particularly in the medullary region
These cognitive impairments may either exacerbate depressive symptoms or arise from shared neurobiological mechanisms, such as disrupted lipid metabolism affecting neuronal function and integrity
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