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(99) demonstrated that Gpx4 expressed in myeloid cells plays a crucial role in lipid peroxidation, inflammasome activation, and release of DAMPs in the setting of sepsis, with Gpx4 deletion leading to increased lethality in sepsis conditions

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In addition, diabetes alters the antioxidant capacity of the heart, which is shown in the decreases in enzymatic (catalase, superoxide dismutase, glutathione peroxidase etc.) and non-enzymatic antioxidant defenses (vitamins A, E, or C) [140]

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