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Interestingly, tamoxifen acting mostly as an anti-estrogen compound has potential for causing cognitive side effects (Novick et al., 2020), given the neuroprotective property of central estrogen, but the true effects of tamoxifen as an estrogen antagonist or agonist appear to depend on the background concentration of endogenous ligand (partial agonist at low estrogen concentration, for example,) (Paige et al., 1999)

Creatine has shown neuroprotective effects by reducing the loss of dopaminergic neurons, especially against the toxicity of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a neurotoxin that produces symptoms similar to PD

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