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, relapse (10, 11), poor healing of the fistulas (35), unhealed intestinal anastomosis (42, 43), massive intestinal resection leading to short bowel (43), and functional incapability of the post-anastomotic remained intestine (43), and, along with these, particularly for multiple sclerosis, direct demonstration of the healing of the severely injured muscles and severely injured nerves and brain injuries (15-23, 59) so far not mentioned with DMDs (61), these results obtained in two models, cysteamine enema and then colon-colon anastomosis and cuprizone may define a particular way not relied on immunomodulation