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Consider them non-negotiable during therapy

A completed PRISMA 2020 checklist is detailed in Supplementary Table S2 and flow diagram were included to ensure transparent and comprehensive reporting

OR Have a BMI of at least 30 with CVD or chronic kidney disease, and/or at least two weight-related complications or risk factors for CVD Have previously tried to lose weight through dietary changes People who have type 1 diabetes or who have tried a GLP-1 within the past 3 months are not eligible

This mechanism differs fundamentally from older weight loss approaches because it addresses the hormonal and neurological drivers of overeating rather than relying purely on willpower or caloric restriction

Geography matters too