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SGLT-2 is expressed in the proximal tubule and mediates re-absorption of ~90% of filtered glucose Rx of Heart Failure : There is accumulating evidence for numerous additional mechanisms of action separate from SGLT2 inhibition that may underlie the ability of gliflozins to produce favorable outcomes in the treatment of heart failure

Metabolic Impact Metabolic health was another area both drugs excelled

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It has been difficult to understand how L-cells in the distal ileum can be exposed to nutrients minutes after their ingestion [31]

Pause the dose increase in agreement with your doctor, optimise your diet, and only titrate further once things have normalised