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Oct 2012;286(4):1033-1040

Can peptides shut down your natural hormone production

Endnotes and References The efficacy estimand represents efficacy had all randomized participants remained on study intervention (with possible dose interruptions and/or dose modifications) for 52 weeks without initiating prohibited weight management treatments, and assuming participants who took rescue orforglipron would not have received any additional improvement from their randomized study treatment

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Multi-institutional research found mean testosterone improved by 49.9% in men starting with levels around 362 ng/dL