Topical glutathione formulations also exist but are widely considered the least effective delivery method because glutathione molecules are too large to penetrate the skin effectively in their intact form
These can include: Nausea, Vomiting, Diarrhea, Stomach upset or pain, Bloating, Headache, Skin rash or allergic reactions (itching, hives, swelling), Fatigue
[ CrossRef ] [ Google scholar ] Pickart L
Beginning with SC MTX should also be taken into consideration due to its advantageous pharmacokinetic profile and absorption (Tornero Molina et al
In the last few years, various GSH modulation-enhanced combinational therapy strategies have been extensively exploited, accompanied by the development of versatile metal-based nanosystems with different structures, functionalities, and treatment performances ( In view of the rapid development of GSH-responsive and -exhausting metal nanomedicines in potentiating cancer therapy, we summarize and outline the recent advancements, mechanisms, prospects, and challenges in this field from different strategies (Scheme 1)