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Additionally, certain bacterial strains may influence bile acid metabolism and reduce low-grade inflammation, both of which affect incretin hormone production

These include modulation of orexin signaling and the HPA axis in opioid models, engagement of lateral septal and habenular circuits in psychostimulant models, and dopamine catabolism and hippocampal effects in alcohol paradigms

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277,278,279,280 This effect is accomplished through the inhibition of JNK, NF-B, and other relevant signaling pathways