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Treatment typically starts with a lower dose (0.25 mg weekly for 4 weeks), which is then increased to 0.5 mg, with further increases to 1 mg or 2 mg if needed for glycaemic control

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This may reflect a local protective response to prevent penetration of the gut by bacterial products and contribute to the anti-inflammatory actions of Ex-4 in the intestine (Kissow et al., 2013)

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However, it has become important to confirm the clinical relevance and durability of the potential benefits in different population groups who are not necessarily required to lose weight through well-designed and adequately powered trials