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However, the underlying mechanism by which MTX provokes tissue injury is not yet well known, and direct toxic effects of MTX are thought to be caused by excessive generation of free radicals, causing an imbalance between free radical production and antioxidant defense, which finally results in the development of oxidative stress (Drishya et al

(2-4) L-Carnitine L-Carnitine : Patients undergoing kidney dialysis can develop a functional carnitine deficiency known as dialysis-related carnitine disorder

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