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Wharton, S., Calanna, S., Davies, M., Dicker, D., Goldman, B., Lingvay, I., Mosenzon, O., Rubino, D
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by transplanting fecal communities from clinically verified responder or non-responder human phenotypes into germ-free rodent models, investigators can systematically isolate and verify the causal contribution of specific microbial configurations to incretin drug efficacy
By controlling for BMI, diabetes, and other health factors, the study strengthens the link between GLP-1 exposure and enhanced sperm count, suggesting a potential therapeutic role for GLP-1s in male infertility management