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Brain Res Rev 25: 335358

MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function

It has been utilized in clinical trials to treat heart and kidney disease connected to hypertension and other chronic diseases by blocking MR signaling with MR antagonists (MRAs), which suppresses fibrosis in these organs as MRAs likely have cardio-protective effects by directly blocking cardiac and vascular MR (72, 73)

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