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This effect might be explained that targeted nanocarriers help the internalization of ibuprofen and its anti-inflammatory action in brain endothelial cells

Nanoparticle-mediated brain drug delivery: Overcoming bloodbrain barrier to treat neurodegenerative diseases

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Palmitoylated proteins are modified by the attachment of fatty acid to cysteine residues via thioester linkage

ROS can further activate epithelial cells and macrophages facilitating neutrophil, monocyte, and lymphocyte recruitment, and the recruited activated inflammatory cells subsequently enhance additional ROS generation, increasing the pro-oxidant burden (8085)