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The mRNA levels of inflammatory factors and cell adhesion factors were increased in the DKD group compared with the CON group, including Tnf , Il1b , Il6 , Icam1 and Vcam1 , but significantly decreased after HU treatment (Figures 3AE)

In human studies, it was described as 'incredibly safe' with no lethal dose ever identified in animal studies

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However, given the greater improvements in HbA1c seen with oral semaglutide throughout the PIONEER trial program, this assumption is likely to be conservative from the oral semaglutide perspective

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