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doi: 10.1093/europace/euac144

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15 Pharmacologic Considerations of the Subcutaneous Route (PMC)Subcutaneous injection technique and site rotation to prevent lipohypertrophy

Initial response time also depends on: Severity of the B12 deficiency Frequency of injections Underlying health conditions Absorption and metabolism differences If youre getting your first B12 shot, your provider may start you on a more aggressive schedule, such as weekly injections until your levels are normalized