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The mechanism suggests that increased therapeutic concentrations in the brain are due to EGCG stabilization in NP complexes and a destabilized BBB [45]

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This is especially important if you experience symptoms commonly associated with high vitamin B12 levels in the blood, including: 9 Gastrointestinal issues, such as nausea, vomiting, or diarrhea Headaches Tingling sensations in the hands and feet Weakness and fatigue Should I Be Concerned About High Vitamin B12 Levels

Tumor heterogeneity further complicates this landscape, as the extent of GSH dependency varies across tumor types, metabolic states, and microenvironments, with poorly defined consequences for therapeutic response

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