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Alterations in neuronal glutamate levels, such as by fluxes to and from a glutathione reservoir, might have an impact upon glutamate neurotransmitter

Levels decline ~50% between ages 40-60

Journal of Clinical Endocrinology & Metabolism, 103(6), 2291-2301

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Our findings should be viewed as being significant but tentative, as future studies are needed to examine these questions in a much larger and more diverse population, notes Joseph Rizzo, the studys co-author and Simmons Lessell Professor of Ophthalmology at Harvard Medical School