Immunohistochemistry Tissues were collected as previously described 27
Introduction Excitotoxicity has been implicated in many neurological disorders including, but not limited to, Alzheimers (Figure 1 illustrates the self-sustaining interaction between excitotoxicity, oxidative stress, and inflammation (which are reviewed below), while also presenting some nutritional deficiencies which can fuel the triad
The authors first synthesized a carborane-based COF (B-COF) ( Figure 14B ), which was then coated with DSPE-PEG to improve dispersion stability, yielding PEG-B-COF
However, a number of factors, including dose, formulation, and type of study population, affect the bioavailability of tocotrienols and may undermine their putative efficacy in humans (14)
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