You don't know the purity, you don't know if there are contaminants, and you can't trust your data
use in cats with current or historical diabetes mellitus has not been evaluated and may not be appropriate
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This is, however, unlikely to affect the signal provided by the probe, which is based on ratiometry [28]
however, it has been hypothesized that the presence of extracellular HMGB1 contributes to selective vulnerability of neuronal subpopulations (e.g., pyramidal and granule cell neurons) to hyperexcitability and synaptic dysfunction within the inflammatory environment, further augmenting seizure activity [48,51]