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A specific type of TRx (f-type) has been shown to be glutathionylated on a cysteine residue away from its active site, resulting in a decreased activity towards specific target proteins including NADP-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) [189]

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Recent analysis by the American Academy of Actuaries suggested that the high cost of these medications, combined with the need for long-term use, could place upward pressure on 2025 health insurance premiums, particularly as more patients met clinical criteria for covered diagnoses

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