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Ask what symptoms should be evaluated first, whether labs or stool testing are appropriate, what the research actually supports, what is still unknown, how safety would be monitored, and how progress would be measured

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Therapeutic implications and future directions Currently, the available evidence demonstrates that region-specific BBB dysfunction including reduced CBF (shortfalls and dysregulations), impaired BBB integrity (increased BBB permeability and transport system), and vascular inflammation (extravasated plasma components and peri-vascular inflammatory responses) contributes to the onset and progression of multiple neurodegenerative disorders