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You get a nice drop in blood pressure with no hypoglycemia. Pioglitazone has similarly shown a durable HbA1c reduction over 5 years and also improves insulin secretion and insulin sensitivity, reverses lipotoxicity and improves markers of nonalcoholic fatty liver disease, DeFronzo said
28 However, oral therapy does not improve serum methylmalonic acid levels as well as intramuscular therapy, although the clinical relevance is unclear
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