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In the SURMOUNT-1 trial, 2,539 overweight or obese participants with at least one comorbid condition (e.g., hypertension, dyslipidemia, and obstructive sleep apnea) were randomized 1:1:1:1 to either tirzepatide or placebo as an adjunct to a low-calorie diet and increased physical activity

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Compared with Control cells, p53 KO cells exhibited far fewer nutlin-3induced changes in gene expression, consistent with most changes observed in Control cells being p53-dependent (Fig 3A)

Athletes bear strict liability for what enters their bodies