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The most effective concentration of HGF (10 ng/ml) was subsequently found to stimulate hippocampal neurons in organotypic hippocampal slice cultures which are more intact preparations similar to Dihexa (Figure 8A and B) further establishing a mechanistic link between Dihexa and HGF/c-Met

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Additional investigations have examined the peptides potential influence on nitric oxide pathways and vascular signaling involved in tissue regeneration