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Oral supplements face challenges in the digestive system, where absorption can be low, mainly in those with certain gut issues
These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes, including amlodipine and the angiotensin II receptor blocker (ARB) class to which valsartan principally belongs
Vitamin E is able to cross the BBB by passive diffusion and accumulate at therapeutic levels in the CNS (Table 2) 91 , 92
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