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Previously, a study based on proteomic analysis had revealed marked transcriptional repression of other Nrf2-induced antioxidant proteins including CK2, ERK1/2, PKC, GPx, Mgst1, peroxiredoxin 3 (Prdx3), in both preclinical models and in human spinal MNs from ALS patients [253]
RSL3 was injected intraperitoneally at 50 mg/kg dosage every 3 days
Moisture escapes
Reconstituted 5-Amino-1MQ stored at 28C in bacteriostatic water maintains peptide purity above 98% for 28 days, based on stability data from lyophilised peptide studies published in pharmaceutical journals
For researchers running dose-escalation studies or comparing multiple dosing regimens simultaneously, smaller vial sizes (5mg/5mg or 6mg/6mg) offer flexibilityeach subject cohort can be assigned a dedicated vial, minimizing cross-contamination risk and simplifying dose tracking
