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The translational pathway would benefit from early thoughts from materials science, clinical, and regulatory experts to co-design delivery formats (e.g., special nanocomposite antimicrobial coatings that rapidly kill persisters on catheters) and to co-plan staged clinical trials with microbiological markers of success (i.e., MBEC reduction and no relapse) and not just surrogates of colonization

Uses: Primary systemic carnitine deficiency Acute and chronic treatment of inborn errors of metabolism resulting in secondary carnitine deficiency Prevention and treatment of carnitine deficiency in end stage renal disease patients undergoing dialysis (IV form only) Usual Pediatric Dose for Carnitine Deficiency METABOLIC DISORDERS: Oral solution or tablets: Initial dose: 50 mg/kg/day orally in evenly divided doses Maintenance dose: 50 to 100 mg/kg/day orally in evenly divided doses Maximum dose: 3 grams per day Intravenous solution: 50 mg/kg as a slow 2 to 3 minute bolus or by infusion, once a day A loading dose may be given in severe metabolic crisis, followed by an equivalent dose every 3 to 4 hours (but not less often than every 6 hours) over the following 24 hours Subsequent daily doses should be in the range of 50 mg/kg or as therapy may require The highest dose administered has been 300 mg/kg

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