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Interestingly, the data supporting the use of GLP-1RAs come from normoglycemic animals

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Because natural GLP-1 is rapidly broken down by DPP-4 in one to two minutes, it would need to be either administered continuously, or researchers would need to produce a mimic with improved stability that would last longer in the bloodstream

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3.3 Beyond drug integration GLP-1 therapies offer a unique opportunity to build ecosystems beyond the drug itself