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7 The inflammation causes cellular damage, and then free radicals, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), were accumulated, resulting in oxidative stress

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Boxes represent the interquartile ranges where a median is the middle vertical line in a box

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The approval of XPOVIO was based upon the efficacy and safety in a prespecified subgroup analysis of the 83 patients whose disease was refractory to bortezomib, carfilzomib, lenalidomide, pomalidomide, and daratumumab, as the benefit-risk ratio appeared to be greater in this more heavily pretreated population than in the overall trial population