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In multiple human and mouse cancer cell lines, as well as in rat fibroblasts and Pfa1 cells overexpressing FSP1, the concurrent use of viFSP1 and the GPX4 inhibitor RSL3 synergistically enhanced ferroptosis induction, suggesting its potential therapeutic utility in tumor treatment (104)

Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin inflammation

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By bypassing the digestive tract, nutrients are delivered straight into the bloodstreamallowing for maximum absorption and faster results

However, the high concentration of GSH within cancer cells is also a major contributor to resistance against conventional therapies such as chemotherapy, radiotherapy, and various dynamic treatments