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Materials and methods Ethics statement All animal experimental procedures in this study were approved and carried out in strict accordance with guidelines for the care and use of animals of the Animal Care and Use Committee at China Agricultural University (approval number CAU20140910-2)

45 Dysfunctions in KARs have been associated with conditions such as anxiety, schizophrenia, epilepsy, neuropathic pain, and migraine

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Progression to periodontitis If gingivitis is left untreated, it can advance to periodontitis, a more severe form of gum disease