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The gene for SDF-1 has been identified through genome-wide association studies as one of the key loci associated with increased susceptibility to coronary artery disease [19, 20]

Childhood and adolescent obesity rates have tripled over the past four decades, and the metabolic consequences of early-onset obesity, including type 2 diabetes, fatty liver disease, and cardiovascular risk factors, are appearing at progressively younger ages

For women of childbearing potential, note that GLP-1 medications for weight management are contraindicated during pregnancy, and some agents should be discontinued at least two months before planned conception

Nicolay JP, Schneider J, Niemoeller OM, Artunc F, Portero-Otin M, Haik G Jr., et al

Jobe, T