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It is not approved for human or animal use and must not be incorporated into foods, cosmetics, medications, or diagnostic applications

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For example, traditional antidepressants, including tricyclic and tetracyclic medications (also known as TCAs) like amitriptyline and nortriptyline, and monoamine oxidase inhibitors (MAOI inhibitors) like phenelzine and isocarboxazid, have a history of causing a range of cardiovascular side effects including increased blood pressure, increased heart rate, arrhythmias, and even heart blocks