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Studies on cortisol and weight show that chronically stressed individuals have measurably slower metabolic rates than their relaxed counterparts, even with identical diets and exercise levels

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These compounds, termed triagonists or triple agonists, couple the weight-reducing efficacy of GLP-1R, GIPR, and GcgR agonism while simultaneously buffering the glycemic effects of Gcg with dual incretin receptor activation [43,45]