Therefore, in this study, we have used human hepatoma HepG2 cancer cells, a commonly used cell culture model, which has been treated with buthionine sulfoximine (BSO), a GSH depleting agent and N-acetylcysteine (NAC), a precursor of GSH synthesis, to study the implications of altered glutathione metabolism in ASA-induced oxidative stress, redox homeostasis and mitochondrial dysfunctions
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Demeyere, R., Lormans, P., Weidler, B., Minten, J., Van Aken, H., and Flameng, W
This led to GHK initially being classified as a liver cell growth factor