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Interpreting type 1 diabetes risk with genetics and single cell epigenomics

89 Although the majority of studies suggest that an increase in NAD+ drives cellular proliferation, prior investigations have proposed that a decrease in NAD+ levels can lead to genomic instability, subsequently instigating liver tumorigenesis

For example, IL-12 induces the differentiation of CD4 + T cells into Th1 cells, whereas upon co-stimulation with IL-6 and TGF-, CD4 + T cells differentiate into Th17 cells

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